News for Healthier Living

Targeting Epigenetics: New Insights Into Oral Cancer Progression and Treatment

Oral squamous cell carcinoma (OSCC) progresses from seemingly benign preneoplastic lesions, but understanding the epigenetic triggers for this transition remains limited. A new study reveals lysine-specific demethylase 1 (LSD1) as a crucial player in OSCC initiation. The researchers show that inhibiting LSD1 in early-stage lesions, through either genetic knockout or pharmacological agents like SP2509, prevents tumor growth, restores immune function, and halts the progression of OSCC. This groundbreaking research highlights LSD1 inhibition as a potential therapeutic strategy for intercepting OSCC before it becomes invasive, offering new hope for early detection and intervention.

May 7, 2025


May 8 2025

May 7 2025

May 6 2025

May 5 2025

May 2 2025

May 1 2025

April 30 2025

April 29 2025

April 28 2025

April 27 2025

April 26 2025

April 25 2025

April 24 2025